This paper presents a 16-channel closed-loop neuromodulation SoC for human seizure control. The SoC includes a 16-ch signal acquisition unit, a bio-signal processor, a 16-ch adaptive stimulator, and wireless telemetry. The signal acquisition unit amplifies and digitizes the sensed electrocorticogram (ECoG) signals. The digitized data are then processed by bio-signal processor for seizure detection. Once the seizure is detected, the adaptive stimulator generates biphasic stimulation currents to suppress seizure onset. The signal acquisition unit achieves 3.78 NEF and shares electrodes with stimulator. The seizure detection latency is 0.76s and delivered 0.5-3mA biphasic current stimulation. The SoC is powered wirelessly and bidirectional data telemetry is realized through the same pair of coils in 13.56MHz.